For the third-straight game, the Huskers did not get a touchdown in the first half as they trail Purdue 14-6 at the half.
The Boilermakers held Nebraska to just eight yards rushing in the first two quarters.
Quarterback Tanner Lee completed 11 of his first 20 passes for 143 yards, but no touchdowns. Wide receiver De'Mornay Pierson El dropped a would-be touchdown catch in the second quarter.
The Blackshirts secondary was at full strength heading into the game, but has since lost safeties Aaron Williams and Antonio Reed to injury.