Glynn Watson Jr. scored 26 points and Tai Webster had 21 Wednesday night, leading Nebraska to a stunning 87-83 upset of No. 16 Indiana.
The Cornhuskers (7-6, 1-0) snapped Indiana's 26-game home winning streak by finishing with their highest point total of the season in the Big Ten opener for both.
Indiana's last loss at Assembly Hall was to Michigan State on March 7, 2015.
Robert Johnson finished with 19 points and Thomas Bryant had 17 points and 10 rebounds to lead the Hoosiers (10-3, 0-1).
Indiana appeared to have seized control when it took a 42-35 lead early in the second half.
But the Cornhuskers answered with a 13-2 run and rebuilt a seven-point lead with 9 minutes to go.